Manchester City go into the game top of the Premier League, eight points clear of second-placed Manchester United, following a last-gasp 2-1 triumph over West Ham.
Manchester United won their last Premier League game 3-1 at Arsenal.
When and where
The game will be played at Old Trafford on Sunday 10 December, kick-off at 4.30pm (GMT).
The game will be shown live in the UK via Sky Sports. View our list of global TV channels showing the game.
City remain without long-term absentee Benjamin Mendy, who is still recovering from anterior cruciate ligament damage, while John Stones is sidelined with a hamstring injury.
David Silva has fully recovered from his slight knock and Pep has confirmed that he is ready to face United.
Manchester United are without Michael Carrick. Eric Bailly is doubtful and Phil Jones and Marouane Fellaini face late fitness tests. Nemanja Matic missed United’s Champions League game against CSKA Moscow but is expected to play.
Paul Pogba is suspended.
Michael Oliver takes charge on Sunday.
The Last Time
The teams met three times last season, the last of which was at the Etihad where the sides drew 0-0.
Prior to that, United won 1-0 at Old Trafford in the League Cup and the Blues triumphed 2-1 in the Premier League meeting in September 2016.